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. 1990 Apr 25;179(3):469-71.
doi: 10.1016/0014-2999(90)90191-8.

Norepinephrine and serotonin increase the vasoconstrictor response of the perfused rat tail artery to changes in cytosolic Ca2+

N Thorin-Trescases  1 , L Oster, J Atkinson, C Capdeville
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Norepinephrine and serotonin increase the vasoconstrictor response of the perfused rat tail artery to changes in cytosolic Ca2+

N Thorin-Trescases et al. Eur J Pharmacol. .

Abstract

Vasoconstriction and changes in cytosolic free Ca2+ concentrations (fura 2 with dual wavelength excitation) were measured simultaneously in the perfused tail artery of the rat. Vasoconstrictors (norepinephrine and 5-HT) appear to modulate contraction not only by changing the cytosolic free Ca2+ concentration but also by modifying the sensitivity of the contractile proteins to Ca2+.

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