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Review
. 2013 May 27;14(8):917-26.
doi: 10.1002/cbic.201300098. Epub 2013 May 3.

Recent advances in the study of enzyme promiscuity in the tautomerase superfamily

Bert-Jan Baas  1 , Ellen Zandvoort, Edzard M Geertsema, Gerrit J Poelarends
Affiliations
Review

Recent advances in the study of enzyme promiscuity in the tautomerase superfamily

Bert-Jan Baas et al. Chembiochem. .

Abstract

Catalytic promiscuity and evolution: Many enzymes exhibit catalytic promiscuity--the ability to catalyze reactions other than their biologically relevant one. These reactions can serve as starting points for both natural and laboratory evolution of new enzymatic functions. Recent advances in the study of enzyme promiscuity in the tautomerase superfamily are discussed.

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