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Comment
. 2013 Jun 18;110(25):E2257.
doi: 10.1073/pnas.1303459110. Epub 2013 May 6.

Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization

David G Mottershead, Craig A Harrison, Thomas D Mueller, Peter G Stanton, Robert B Gilchrist, Kenneth P McNatty
Comment

Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization

David G Mottershead et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Conflict of interest statement: R.B.G. is a consultant to Cook Medical. The University of Adelaide holds a patent on applications of GDF9 and BMP15 (R.B.G. is an inventor).

Figures

Fig. 1.
Fig. 1.
Potential structural forms of BMP15 (solid) and GDF9 (clear) mature regions: monomers (1), heterodimers (2), homodimers (3), and a dimer of homodimers (4). These different forms may well be in a dynamic equilibrium, given that BMP15 and GDF9 mature regions do not form covalent dimers. A further extension of 4 would be higher-order noncovalent multimers or aggregates. All of these forms would result in the same banding pattern in silver-stained SDS/PAGE gels or Western blots.
See this image and copyright information in PMC

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References

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    1. McNatty KP, et al. The oocyte and its role in regulating ovulation rate: a new paradigm in reproductive biology. Reproduction. 2004;128(4):379–386. - PubMed

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