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. 2013 May;14(7):835-43.
doi: 10.2217/pgs.13.52.

Pharmacogenetics in clinical practice: how far have we come and where are we going?

Julie A Johnson  1
Affiliations

Pharmacogenetics in clinical practice: how far have we come and where are we going?

Julie A Johnson. Pharmacogenomics. 2013 May.

Abstract

Recent years have seen great advances in our understanding of genetic contributors to drug response. Drug discovery and development around targeted genetic (somatic) mutations has led to a number of new drugs with genetic indications, particularly for the treatment of cancers. Our knowledge of genetic contributors to variable drug response for existing drugs has also expanded dramatically, such that the evidence now supports clinical use of genetic data to guide treatment in some situations, and across a variety of therapeutic areas. Clinical implementation of pharmacogenetics has seen substantial growth in recent years and groups are working to identify the barriers and best practices for pharmacogenetic-guided treatment. The advances and challenges in these areas are described and predictions about future use of genetics in drug therapy are discussed.

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References

    1. Collins FS, McKusick VA. Implications of the human genome project for medical science. JAMA. 2001;285(5):540–544. - PubMed
    1. Ramsey BW, Davies J, Mcelvaney NG, et al. A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med. 2011;365(18):1663–1672. - PMC - PubMed
    1. Rubin EH, Gilliland DG. Drug development and clinical trials – the path to an approved cancer drug. Nat Rev Clin Oncol. 2012;9(4):215–222. - PubMed
    1. Asselbergs FW, Guo Y, van Iperen EP, et al. Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet. 2012;91(5):823–838. - PMC - PubMed
    1. Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet. 2005;37(2):161–165. - PubMed

Websites

    1. US FDA Table of Pharmacogenomic Biomarkers in Drug Labels. www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm0833....
    1. The Pharmacogenomics Knowledgebase. www.PharmGKB.org.
    1. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in HIV-1-infected Adults and Adolescents. 2011 www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.

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