Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Apr 24;14(4):112.
doi: 10.1186/gb-2013-14-4-112.

The complex binding of PRDM9

Comment

The complex binding of PRDM9

Laure Ségurel. Genome Biol. .

Abstract

A recent study investigates the in vitro DNA binding behavior of PRDM9, a zinc finger protein involved in the localization of recombination hotspots in mammals.

PubMed Disclaimer

Figures

Figure 1
Figure 1
PRDM9 binding predictions and hotspot consensus motifs in humans (A and C variant [3,4]) and mice (C57BL/10.F strain [2]). Binding predictions were obtained from the polynomial model described by Persikov et al. [9].

Comment on

References

    1. Billings T, Parvanov ED, Baker CL, Walker M, Paigen K, Petkov PM. DNA binding specificities of the long zinc finger recombination protein PRDM9. Genome Biol. 2013;4:R35. - PMC - PubMed
    1. Smagulova F, Gregoretti IV, Brick K, Khil P, Camerini-Otero RD, Petukhova GV. Genome-wide analysis reveals novel molecular features of mouse recombination hotspots. Nature. 2011;472:375–378. doi: 10.1038/nature09869. - DOI - PMC - PubMed
    1. Myers S, Freeman C, Auton A, Donnelly P, McVean G. A common sequence motif associated with recombination hot spots and genome instability in humans. Nat Genet. 2008;40:1124–1129. doi: 10.1038/ng.213. - DOI - PubMed
    1. Hinch AG, Tandon A, Patterson N, Song Y, Rohland N, Palmer CD, Chen GK, Wang K, Buxbaum SG, Akylbekova EL, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, Boerwinkle E, Cai Q, Caporaso N, Casey G, Cupples LA, Deming SL, Diver WR, Divers J, Fornage M, Gillanders EM, Glessner J, Harris CC. et al.The landscape of recombination in African Americans. Nature. 2011;476:170–175. doi: 10.1038/nature10336. - DOI - PMC - PubMed
    1. Jeffreys AJ, Neumann R. Factors influencing recombination frequency and distribution in a human meiotic crossover hotspot. Hum Mol Genet. 2005;14:2277–2287. doi: 10.1093/hmg/ddi232. - DOI - PubMed

MeSH terms

LinkOut - more resources