Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Oct;32(10):1077-9.
doi: 10.1097/INF.0b013e318299f75c.

Desired vancomycin trough serum concentration for treating invasive methicillin-resistant Staphylococcal infections

Adam Frymoyer  1 , B Joseph Guglielmo, Adam L Hersh
Affiliations

Desired vancomycin trough serum concentration for treating invasive methicillin-resistant Staphylococcal infections

Adam Frymoyer et al. Pediatr Infect Dis J. 2013 Oct.

Abstract

Vancomycin area under the curve/minimal inhibitory concentration (AUC/MIC) >400 best predicts the outcome when treating invasive methicillin-resistant Staphylococcus aureus infection; however, trough serum concentrations are used clinically to assess the appropriateness of dosing. We used pharmacokinetic modeling and simulation to examine the relationship between vancomycin trough values and AUC/MIC in children receiving vancomycin 15 mg/kg every 6 hours and methicillin-resistant Staphylococcus aureus MIC of 1 μg/mL. A trough of 7-10 μg/mL predicted achievement of AUC/MIC >400 in >90% of children.

PubMed Disclaimer

Comment in

MeSH terms

LinkOut - more resources