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. 2013 Sep;66(9):555-8.
doi: 10.1038/ja.2013.38. Epub 2013 May 8.

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663

Xiangyang Liu  1 , Sreya Biswas, Gong-Li Tang, Yi-Qiang Cheng
Affiliations

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663

Xiangyang Liu et al. J Antibiot (Tokyo). 2013 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Structures of 1, FR901464 and spliceostatin A.
Figure 2
Figure 2
Key COSY and HMBC correlations of 1 (a), and key NOE correlations of 1 fragments (b).
See this image and copyright information in PMC

References

    1. Nakajima H, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo) 1996;49:1204–1211. - PubMed
    1. Nakajima H, et al. New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo) 1996;49:1196–1203. - PubMed
    1. Nakajima H, Takase S, Terano H, Tanaka H. New antitumor substances, FR901463, FR901464 and FR901465. III. Structures of FR901463, FR901464 and FR901465. J Antibiot (Tokyo) 1997;50:96–99. - PubMed
    1. Albert BJ, Sivaramakrishnan A, Naka T, Czaicki NL, Koide K. Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue. J Am Chem Soc. 2007;129:2648–2659. - PMC - PubMed
    1. Motoyoshi H, et al. Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes. Biosci Biotechnol Biochem. 2004;68:2178–2182. - PubMed

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