doi: 10.1039/c3cc42308e.
A bright and responsive europium probe for determination of pH change within the endoplasmic reticulum of living cells
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- PMID: 23652607
- DOI: 10.1039/c3cc42308e
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A bright and responsive europium probe for determination of pH change within the endoplasmic reticulum of living cells
Chem Commun (Camb).
.
Abstract
A ratiometric Eu(III) complex has been developed that localises selectively within the endoplasmic reticulum of living cells. Careful calibration, using a time-gated spectral imaging microscope, allows the intensity ratio of emission bands and the variation of excited state lifetime to be used for pH determination, with a pKa of 7.15.
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