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. 2013 Jun 14;49(47):5363-5.
doi: 10.1039/c3cc42308e.

A bright and responsive europium probe for determination of pH change within the endoplasmic reticulum of living cells

Brian K McMahon  1 , Robert Pal, David Parker
Affiliations

A bright and responsive europium probe for determination of pH change within the endoplasmic reticulum of living cells

Brian K McMahon et al. Chem Commun (Camb). .

Abstract

A ratiometric Eu(III) complex has been developed that localises selectively within the endoplasmic reticulum of living cells. Careful calibration, using a time-gated spectral imaging microscope, allows the intensity ratio of emission bands and the variation of excited state lifetime to be used for pH determination, with a pKa of 7.15.

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