Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 May;5(5):658-60.
doi: 10.1002/emmm.201202763.

Initial HIV mucosal infection and dendritic cells

Anthony L Cunningham  1 , Andrew N Harman, Najla Nasr
Affiliations
Comment

Initial HIV mucosal infection and dendritic cells

Anthony L Cunningham et al. EMBO Mol Med. 2013 May.

Erratum in

  • EMBO Mol Med. 2013 Oct;5(10):1635. Harman, Andrew [corrected to Harman, Andrew N]
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Role of DCs in the penetration of anogenital and intestinal epithelial surfaces by HIV. A. Penetration through the stratified squamous epithelium. HIV comes into contact with Langerhans cells (LC) either by passing between keratinocytes or directly in the presence micro-abrasions or genital ulcers caused by sexually transmitted infections. LCs then migrate to the submucosa or lymph nodes transferring HIV via viral synapses to mostly resting T cells. B. Penetration through the columnar epithelium. HIV initially penetrates the tight junctions between columnar epithelial cells, establishing a viral concentration gradient that induces extension of processes from lamina propria DCs (or emigration of whole DCs), via an interaction with CCR5. Captured and/or replicating HIV is then transferred to activated T cells in the lamina propria. Alternatively, HIV may cross the columnar epithelium by transcytosis.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Anand AR, Prasad A, Bradley RR, Deol YS, Nagaraja T, Ren X, Terwilliger EF, Ganju RK. HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1. Blood. 2009;114:3588–3600. - PMC - PubMed
    1. Cavarelli M, Foglieni C, Rescigno M, Scarlatti G. R5 HIV-1 envelope attracts dendritic cells to cross the human intestinal epithelium and sample luminal virions via engagement of the CCR5. EMBO Mol Med. 2013;5:776–794. - PMC - PubMed
    1. Cunningham AL, Harman A, Kim M, Nasr N, Lai J. Immunobiology of dendritic cells and the influence of HIV infection. Adv Exp Med Biol. 2013;762:1–44. - PubMed
    1. Harman AN, Bye CR, Nasr N, Sandgren KJ, Kim M, Mercier SK, Botting RA, Lewin SR, Cunningham AL, Cameron PU. Identification of lineage relationships and novel markers of blood and skin human dendritic cells. J Immunol. 2013;190:66–79. - PubMed
    1. Harman AN, Lai J, Turville S, Samarajiwa S, Gray L, Marsden V, Mercier SK, Jones K, Nasr N, Rustagi A, et al. HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production. Blood. 2011;118:298–308. - PMC - PubMed

Substances