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Comment
. 2013 Jun 1;12(11):1804-5.
doi: 10.4161/cc.24940. Epub 2013 May 8.

Cellular immortalization and neoplastic transformation: Simultaneous, sequential or independent? Telomeres, telomerase or karyotypic variations?

Affiliations
Comment

Cellular immortalization and neoplastic transformation: Simultaneous, sequential or independent? Telomeres, telomerase or karyotypic variations?

Chiara Mondello et al. Cell Cycle. .
No abstract available

Keywords: cancer; cellular transformation; chromosomal aberration; karyotype; microarray; oncogene; telomerase; telomere; transcription profiling; tumorsuppressor gene.

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References

    1. Harley CB. Telomere loss: mitotic clock or genetic time bomb? Mutat Res. 1991;256:271–82. doi: 10.1016/0921-8734(91)90018-7. - DOI - PubMed
    1. Shay JW, Wright WE. Role of telomeres and telomerase in cancer. Semin Cancer Biol. 2011;21:349–53. doi: 10.1016/j.semcancer.2011.10.001. - DOI - PMC - PubMed
    1. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349–52. doi: 10.1126/science.279.5349.349. - DOI - PubMed
    1. Belgiovine C, Chiodi I, Mondello C. Telomerase: cellular immortalization and neoplastic transformation. Multiple functions of a multifaceted complex. Cytogenet Genome Res. 2008;122:255–62. doi: 10.1159/000167811. - DOI - PubMed
    1. Mondello C, Chiesa M, Rebuzzini P, Zongaro S, Verri A, Colombo T, et al. Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals. Biochem Biophys Res Commun. 2003;308:914–21. doi: 10.1016/S0006-291X(03)01484-0. - DOI - PubMed

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