Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jun;14(6):379-89.
doi: 10.1038/nrg3472. Epub 2013 May 9.

Meta-analysis methods for genome-wide association studies and beyond

Evangelos Evangelou  1 , John P A Ioannidis
Affiliations
Review

Meta-analysis methods for genome-wide association studies and beyond

Evangelos Evangelou et al. Nat Rev Genet. 2013 Jun.

Abstract

Meta-analysis of genome-wide association studies (GWASs) has become a popular method for discovering genetic risk variants. Here, we overview both widely applied and newer statistical methods for GWAS meta-analysis, including issues of interpretation and assessment of sources of heterogeneity. We also discuss extensions of these meta-analysis methods to complex data. Where possible, we provide guidelines for researchers who are planning to use these methods. Furthermore, we address special issues that may arise for meta-analysis of sequencing data and rare variants. Finally, we discuss challenges and solutions surrounding the goals of making meta-analysis data publicly available and building powerful consortia.

PubMed Disclaimer

References

    1. Am J Epidemiol. 2009 Nov 15;170(10):1197-206 - PubMed
    1. Genet Epidemiol. 2010 Feb;34(2):188-93 - PubMed
    1. Nat Genet. 2010 May;42(5):441-7 - PubMed
    1. Nat Rev Genet. 2009 May;10(5):318-29 - PubMed
    1. Genet Epidemiol. 2011 Dec;35(8):867-79 - PubMed

Publication types

LinkOut - more resources