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Editorial
. 2013 Sep 15;305(6):C579-80.
doi: 10.1152/ajpcell.00125.2013. Epub 2013 May 8.

Increasing our IQ of vascular smooth muscle cell migration with IQGAP1. Focus on "IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury"

Michael V Autieri  1
Affiliations
Editorial

Increasing our IQ of vascular smooth muscle cell migration with IQGAP1. Focus on "IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury"

Michael V Autieri. Am J Physiol Cell Physiol. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
IQGAP1 at the center of PDGF-initiated VSMC migration. Upon PDGF stimulation, IQGAP1 interacts with the phosphorylated PDGF receptor. Through its many protein-protein (P) interaction domains, IQGAP1 acts as a hub to congregate GTPases and other proteins that play a role in cell migration into reactive proximity with the focal adhesion complex. Domains in IQGAP1: CHD = calponin homology domain, interacts with F-actin; IQGAP repeat (IQ repeat) = IQGAP-specific repeat motif; WW = WW domain binds ERK1/2; IQ motif binds calmodulin and myosin essential light chain; GRD = Ras GAP-related domain, binds Rac and Cdc42; RasGAP COOH terminus (Ras Gap C), binds ERK1/2 and β-catenin.
See this image and copyright information in PMC

References

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