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Editorial
. 2013 Jul 1;305(1):C24-5.
doi: 10.1152/ajpcell.00119.2013. Epub 2013 May 8.

Potential link between cysteinyl-leukotriene receptors and release of bioactive amino acids in regulation of lung function. Focus on "Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase"

Alexander A Mongin
Editorial

Potential link between cysteinyl-leukotriene receptors and release of bioactive amino acids in regulation of lung function. Focus on "Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase"

Alexander A Mongin. Am J Physiol Cell Physiol. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Hypothetical scheme illustrating possible role of 5-lipoxygenase (5-LO) and cysteinyl-leukotrienes (cys-LT) in regulation of taurine release and respiratory function in health and disease. A: simplified diagram representing the major findings of the work. Swelling of airway epithelial cell (AE) triggers taurine release through the organic osmolyte channel VSOAC due to the ROS-dependent activation of 5-LO and autocrine stimulation of the CysLT1 receptors. Stimuli causing Ca2+ influx or intracellular release, such as activation of G protein-coupled receptors (GPCRs), exert additive influence on 5-LO activity and taurine release. B: tonic (physiological) release of taurine may stimulate mucus secretion by goblet cells (G) or cause relaxation of airway smooth muscle cells (SMC) via activation of the SMC GABAA and/or glycine receptors. C: in asthma, invading blood immune cells, including eosinophils (E) and macrophages (MΦ), release large quantities of cys-LTs. Hyperstimulated taurine release likely contributes to the excessive mucus secretion by goblet cells and formation of mucus plugs in airways. Cys-LTs also act directly on smooth muscle cells as potent constricting agents and blunt any relaxing effects, which otherwise may be caused by taurine.
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