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Editorial
. 2013 Jul 1;305(1):C24-5.
doi: 10.1152/ajpcell.00119.2013. Epub 2013 May 8.

Potential link between cysteinyl-leukotriene receptors and release of bioactive amino acids in regulation of lung function. Focus on "Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase"

Alexander A Mongin
Editorial

Potential link between cysteinyl-leukotriene receptors and release of bioactive amino acids in regulation of lung function. Focus on "Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase"

Alexander A Mongin. Am J Physiol Cell Physiol. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Hypothetical scheme illustrating possible role of 5-lipoxygenase (5-LO) and cysteinyl-leukotrienes (cys-LT) in regulation of taurine release and respiratory function in health and disease. A: simplified diagram representing the major findings of the work. Swelling of airway epithelial cell (AE) triggers taurine release through the organic osmolyte channel VSOAC due to the ROS-dependent activation of 5-LO and autocrine stimulation of the CysLT1 receptors. Stimuli causing Ca2+ influx or intracellular release, such as activation of G protein-coupled receptors (GPCRs), exert additive influence on 5-LO activity and taurine release. B: tonic (physiological) release of taurine may stimulate mucus secretion by goblet cells (G) or cause relaxation of airway smooth muscle cells (SMC) via activation of the SMC GABAA and/or glycine receptors. C: in asthma, invading blood immune cells, including eosinophils (E) and macrophages (MΦ), release large quantities of cys-LTs. Hyperstimulated taurine release likely contributes to the excessive mucus secretion by goblet cells and formation of mucus plugs in airways. Cys-LTs also act directly on smooth muscle cells as potent constricting agents and blunt any relaxing effects, which otherwise may be caused by taurine.
See this image and copyright information in PMC

Comment on

References

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