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Case Reports
. 2014 Feb;40(2):217-20.
doi: 10.1111/nan.12060.

Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations

G Y López  1 , G A Grant, H E Fuchs, L G Leithe, S Gururangan, D D Bigner, H Yan, R E McLendon, Y He
Affiliations
Case Reports

Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations

G Y López et al. Neuropathol Appl Neurobiol. 2014 Feb.
No abstract available

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Figures

Figure
Figure
A) CT demonstrates a hyperdense 3x4 centimeter midline posterior fossa mass that appears to fill the fourth ventricle, containing punctate calcifications and cystic components. B) Haematoxylin and eosin staining of histological sections from Case #1, Case #2, and Case #3. Note that Case #1 demonstrates hyperchromatic, molded nuclei associated with vascular proliferation (arrowhead) and geographic necrosis (arrows) indicative of a severely anaplastic medulloblastoma; geographic necrosis also suggests a lack of differentiation. C) Immunohistochemical assay shows positive OTX2 expression in Case #1 (Score:40% 2+) and Case #2 (Score: 50% 2+).
See this image and copyright information in PMC

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