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Editorial
. 2013 Apr;4(4):500-1.
doi: 10.18632/oncotarget.986.

Jak2V617F myeloproliferative neoplasm stem cells and interferon-alpha

Steven W Lane, Ann Mullaly
Editorial

Jak2V617F myeloproliferative neoplasm stem cells and interferon-alpha

Steven W Lane et al. Oncotarget. 2013 Apr.
No abstract available

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Figures

Figure 1
Figure 1. MPN stem cells are responsible for disease initiation and propagation in vivo
IFNα therapy has direct effects on MPN stem cells leading to depletion of LT-HSCs, exit from quiescence and enforced terminal differentiation. Additionally, IFNα may have direct effects on downstream effector cells leading to reduction in blood counts and extramedullary hematopoiesis. The effects of IFNα on preventing fibrotic and/or leukemic transformation have not yet been defined
See this image and copyright information in PMC

References

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    1. Harrison C, et al. The New England journal of medicine. 2012;366(9):787–798. - PubMed
    1. Quintas-Cardama A, et al. J Clin Oncol. 2009;27(32):5418–5424. - PMC - PubMed

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