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Comment
. 2013 May 10;340(6133):682.
doi: 10.1126/science.1233195.

Comment on "Evidence of abundant purifying selection in humans for recently acquired regulatory functions"

Phil Green  1 , Brent Ewing
Affiliations
Comment

Comment on "Evidence of abundant purifying selection in humans for recently acquired regulatory functions"

Phil Green et al. Science. .

Abstract

Ward and Kellis (Reports, 28 September 2012, p. 1675; published online 5 September 2012) found altered patterns of human polymorphism in biochemically active but non-mammalian-conserved genomic regions relative to control regions and interpreted this as due to lineage-specific purifying selection. We find on closer inspection of their data that the polymorphism trends are primarily attributable to mutational variation and technical artifacts rather than selection.

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