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. 2013 May 10;340(6133):689-90.
doi: 10.1126/science.1239101.

Genetics. Simple genetics for a complex disease

Jonathan C Cohen  1 , Helen H Hobbs
Affiliations

Genetics. Simple genetics for a complex disease

Jonathan C Cohen et al. Science. .

Abstract

Low-frequency alleles with large phenotypic effects may guide the development of therapeutics and treatments.

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Figures

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Rerouting. The intracellular pathways of the LDL receptor after binding LDL or PCSK9 are shown. Antibodies that target PCSK9 prevent the rerouting and degradation of LDL receptors, thereby reducing plasma concentrations of LDL. EGF, epidermal growth factor.
See this image and copyright information in PMC

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