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Randomized Controlled Trial
. 2013 May 11:14:136.
doi: 10.1186/1745-6215-14-136.

Update on the collaborative interventions for circulation and depression (COINCIDE) trial: changes to planned methodology of a cluster randomized controlled trial of collaborative care for depression in people with diabetes and/or coronary heart disease

Peter A Coventry  1 , Karina Lovell, Chris Dickens, Peter Bower, Carolyn Chew-Graham, Andrea Cherrington, Charlotte Garrett, Chris J Gibbons, Clare Baguley, Kate Roughley, Isabel Adeyemi, Chris Keyworth, Waquas Waheed, Mark Hann, Linda Davies, Farheen Jeeva, Chris Roberts, Sarah Knowles, Linda Gask
Affiliations
Randomized Controlled Trial

Update on the collaborative interventions for circulation and depression (COINCIDE) trial: changes to planned methodology of a cluster randomized controlled trial of collaborative care for depression in people with diabetes and/or coronary heart disease

Peter A Coventry et al. Trials. .

Abstract

Background: The COINCIDE trial aims to evaluate the effectiveness and cost-effectiveness of a collaborative care intervention for depression in people with diabetes and/or coronary heart disease attending English general practices.

Design: This update details changes to the cluster and patient recruitment strategy for the COINCIDE study. The original protocol was published in Trials (http://www.trialsjournal.com/content/pdf/1745-6215-13-139.pdf). Modifications were made to the recruitment targets in response to lower-than-expected patient recruitment at the first ten general practices recruited into the study. In order to boost patient numbers and retain statistical power, the number of general practices recruited was increased from 30 to 36. Follow-up period was shortened from 6 months to 4 months to ensure that patients recruited to the trial could be followed up by the end of the study.

Results: Patient recruitment began on the 01/05/2012 and is planned to be completed by the 30/04/2013. Recruitment for general practices was completed on 31/10/2012, by which time the target of 36 practices had been recruited. The main trial results will be published in a peer-reviewed journal.

Conclusion: The data from the trial will provide evidence on the effectiveness and cost-effectiveness of collaborative care for depression in people with diabetes and/or coronary heart disease.

Trial registration number: ISRCTN80309252.

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References

    1. Coventry PA, Lovell K, Dickens C, Bower P, Chew-Graham C, Cherrington C, Garrett C, Gibbons CJ, Baguley C, Roughley K, Adeyemi I, Keyworth C, Waheed W, Hann M, Davies L, Jeeva F, Roberts C, Knowles S, Gask L. Collaborative interventions for circulation and depression (COINCIDE): study protocol for a cluster randomized controlled trial of collaborative care for depression in people with diabetes and/or coronary heart disease. Trials. 2012;13:139. doi: 10.1186/1745-6215-13-139. - DOI - PMC - PubMed
    1. Chalder M, Wiles NJ, Campbell J, Hollinghurst SP, Haase AM, Taylor AH, Fox KR, Costelloe C, Searle A, Baxter H, Winder R, Wright C, Turner KM, Calnan M, Lawlor DA, Peters TJ, Sharp DJ, Montgomery AA, Lewis G. Facilitated physical activity as a treatment for depressed adults: randomised controlled trial. BMJ. 2012;344:e2758. doi: 10.1136/bmj.e2758. - DOI - PMC - PubMed
    1. Medical Research Council. Guidelines for Good Clinical Practice. London: Medical Research Council; 1998.

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