Lymphatics as a new active player in reverse cholesterol transport
- PMID: 23663731
- DOI: 10.1016/j.cmet.2013.04.017
Lymphatics as a new active player in reverse cholesterol transport
Abstract
Reverse cholesterol transport (RCT), a key function of high-density lipoproteins (HDL), prevents excess cholesterol in tissues. A study in this issue (Lim et al., 2013) suggests that lymphatic vessels are critical for normal RCT and mediate the active trans-endothelial transport of HDL via the HDL receptor SR-BI.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL.Cell Metab. 2013 May 7;17(5):671-84. doi: 10.1016/j.cmet.2013.04.002. Cell Metab. 2013. PMID: 23663736
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