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Comment
. 2013 May 7;17(5):629-30.
doi: 10.1016/j.cmet.2013.04.004.

miR-34a and the cardiomyopathy of senescence: SALT PNUTS, SALT PNUTS!

Gerald W Dorn 2nd  1
Affiliations
Comment

miR-34a and the cardiomyopathy of senescence: SALT PNUTS, SALT PNUTS!

Gerald W Dorn 2nd. Cell Metab. .

Abstract

The search for eternal youth is age old. In a recent Nature paper, Boon et al. (2013) describe DNA damage mechanisms and cardiac senescence provoked by miR-34a and its target, PNUTS. Interrupting this pathway may prevent age- and stress-induced cardiac degeneration.

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Figures

Figure
Figure. Simplified schematic of miR-34a/PNUTS and related signaling pathways that determine cell survival, senescence, and programmed death
DNA damage activates tumor suppressor p53, initiating p53 activity-dependent DNA repair (blue), senescence/cell cycle arrest (yellow), and apoptosis signaling (red) pathways. miR-34a expression is increased by p53, and feeds back to p53 via its mRNA target, the anti-aging/cell survival factor SIRT1 (green). As shown in Boon et al, miR-34a also targets PNUTS, which is a multifunctional modulator of cell growth (green), cell death, and DNA damage repair pathways. Critical effectors of the various pathways are indicated. mCpG indicates DNA hypermethylation. RISC is RNA-Induced Silencing Complex.
See this image and copyright information in PMC

Comment on

  • MicroRNA-34a regulates cardiac ageing and function.
    Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, Horrevoets AJ, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S. Boon RA, et al. Nature. 2013 Mar 7;495(7439):107-10. doi: 10.1038/nature11919. Epub 2013 Feb 20. Nature. 2013. PMID: 23426265

References

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