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Comment
. 2013 May 7;17(5):633-5.
doi: 10.1016/j.cmet.2013.04.018.

mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis

Gwen R Buel  1 , Sang Gyun Kim, John Blenis
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Free article
Comment

mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis

Gwen R Buel et al. Cell Metab. .
Free article

Abstract

Mechanistic target of rapamycin complex 1 (mTORC1) regulates growth and metabolism by integrating signals from the cellular environment. Ben-Sahra et al. (2013) and Robitaille et al. (2013) demonstrate a role for mTORC1 in nucleotide production via S6K1 phosphorylation of CAD, which catalyzes the initial steps of de novo pyrimidine biosynthesis.

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