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Comment
. 2013 May 7;17(5):635-7.
doi: 10.1016/j.cmet.2013.04.016.

Rejuvenating SIRT1 activators

Philipp Gut  1 , Eric Verdin
Affiliations
Free article
Comment

Rejuvenating SIRT1 activators

Philipp Gut et al. Cell Metab. .
Free article

Abstract

Whether the red wine component resveratrol directly activates the NAD(+)-dependent protein deacetylase SIRT1 has been debated. A recent study by Hubbard et al. (2013) strengthens the case that SIRT1-activating compounds (STACs) function as positive allosteric regulators of SIRT1 and thereby regulate mitochondrial function.

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  • Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
    Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Hubbard BP, et al. Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097. Science. 2013. PMID: 23471411 Free PMC article.

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