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Comment
. 2013 May 8;78(3):405-8.
doi: 10.1016/j.neuron.2013.04.034.

RAN translation: fragile X in the running

Kaalak Reddy  1 , Christopher E Pearson
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RAN translation: fragile X in the running

Kaalak Reddy et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Todd et al. (2013) reveal that noncanonical repeat associated non-AUG (RAN) translation occurs on nonexpanded (CGG)30-50 and premutation (CGG)59-160 repeats, associated with the FMR1 gene, suggesting that the polyglycine and polyalanine products might have natural and pathogenic roles.

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