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Review
. 2013 May;24(5):507-13.
doi: 10.1016/j.semcdb.2013.04.004. Epub 2013 May 9.

Coupling the cell cycle to development and regeneration of the inner ear

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Review

Coupling the cell cycle to development and regeneration of the inner ear

Thomas Schimmang et al. Semin Cell Dev Biol. 2013 May.

Abstract

Cell cycle exit and acquirement of a postmitotic state is essential for the proper development of organs. In the present review, we examine the role of the cell cycle control in the sensory epithelia of the mammalian inner ear. We describe the roles of the core cell cycle regulators in the proliferation of prosensory cells and in the initiation and maintenance of terminal mitosis of the sensory epithelia. We also discuss how other intracellular signalling may influence the cell cycle. Finally, we address the question of whether manipulations of the cell cycle may have the potential to create replacement cells for the damaged inner sensory epithelia.

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