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. 2013 Apr;47(2):130-6.
doi: 10.4132/KoreanJPathol.2013.47.2.130. Epub 2013 Apr 24.

Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma

Jiyeon Hyeon  1 , Soomin Ahn, Jae Jun Lee, Dae Hyun Song, Cheol-Keun Park
Affiliations

Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma

Jiyeon Hyeon et al. Korean J Pathol. 2013 Apr.

Abstract

Background: BCL9 enhances β-catenin-mediated transcriptional activity regardless of the mutational status of the Wnt signaling components and increases the cell proliferation, migration, invasion, and metastatic potential of tumor cells. The goal of this study was to elucidate the prognostic significance of BCL9 protein expression in hepatocellular carcinoma (HCC) patients.

Methods: We evaluated BCL9 protein expression by immunohistochemistry in tumor tissue from 288 primary HCC patients who underwent curative hepatectomy. The impact of BCL9 expression on the survival of the patients was analyzed. The median follow-up period was 97.1 months.

Results: Nuclear BCL9 protein expression was observed in 74 (25.7%) of the 288 HCCs. BCL9 expression was significantly associated with younger age (p=0.038), higher Edmondson grade (p=0.001), microvascular invasion (p=0.013), and intrahepatic metastasis (p=0.017). Based on univariate analyses, BCL9 expression showed an unfavorable influence on both disease-free survival (DFS, p=0.012) and disease-specific survival (DSS, p=0.032). Multivariate analyses revealed that higher Barcelona Clinic Liver Cancer stage was an independent predictor of both shorter DFS (p<0.001) and shorter DSS (p<0.001). BCL9 expression tended to be an independent predictor of shorter DFS (p=0.078).

Conclusions: BCL9 protein expression might be a marker of shorter DFS in HCC patients after curative hepatectomy.

Keywords: BCL9; Carcinoma, hepatocellular; Recurrence; Survival.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Immunostaining of BCL9 showing nuclear expression in hepatocellular carcinoma (A) and no nuclear expression in dysplastic nodule (B) (horseradish peroxidase stain).
Fig. 2
Fig. 2
Kaplan-Meier survival curves showing disease-free survival (A) and disease-specific survival (B) for BCL9 expression in 288 hepatocellular carcinomas.
See this image and copyright information in PMC

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