Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jun 1;7(2):73-80.
doi: 10.1016/j.artres.2013.01.003.

The reality of aging viewed from the arterial wall

Edward G Lakatta  1
Affiliations

The reality of aging viewed from the arterial wall

Edward G Lakatta. Artery Res. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Reality is a system of mutually enslaved DNA and its environment.
Figure 2
Figure 2
Remaining lifetime risk for CVD and other diseases among men and women free of disease at 40 and 70 years of age.
Figure 3
Figure 3
PWV predicts future blood pressure rise and development of hypertension.
Figure 4
Figure 4
Aging of large arteries: inflammation.
Figure 5
Figure 5
Proinflammatory mechanisms of age-associated arterial remodeling.
Figure 6
Figure 6
MFG-E8 stimulates proliferation and invasion in VSMC, and its medin degradation product may play a role in increased arterial stiffness.
Figure 7
Figure 7
Age-associated matrix remodeling of central arteries.
Figure 8
Figure 8
Key roles of matrix metalloprotease in age-associated changes in aortic wall phenotypes.
Figure 9
Figure 9
Chronic Matrix Metalloprotease Inhibition (MMPI) prevents an age-associated increase in arterial pressure in rats.
Figure 10
Figure 10
Chronic arterial inflammation and arterial remodeling during aging are strikingly similar to hypertension, atherosclerosis, and diabetes mellitus.
See this image and copyright information in PMC

References

    1. Lakatta EG, Wang M, Najjar S. Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels. Med Clin North Am. 2009;93:583–604. - PMC - PubMed
    1. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, et al. on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2010 update: a report from the American Heart Association. Circulation. 2010;121:e46–215. - PubMed
    1. Najjar SS, Scuteri A, Gill V, Wright JG, Muller DC, Flag JL, et al. Pulse wave velocity is an independent predictor of the longitudinal rise in systolic blood pressure and of incident hypertension in the Baltimore longitudinal study of aging. J Am Coll Cardiol. 2008;51:1377–83. - PMC - PubMed
    1. Wang M, Zhang J, Jian L-Q, Spinetti G, Pintus G, Monticone R, et al. A proinflammatory profile within the grossly normal human aortic wall accompanies advancing age. Hypertension. 2007;50:219–27. - PubMed
    1. Wang M, Lakatta EG. Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging. Hypertension. 2002;39:865–73. - PubMed