Dynamics of lipid peroxidation-antioxidant defense system during alloxan diabetes in rats

Abstract

We studied the dynamics of lipid peroxidation-antioxidant defense system in rat model of alloxan diabetes and compared it with disorders of carbohydrate and lipid metabolism. It was found that rats not treated with insulin developed hyperglycemia, hypertriglyceridemia, hypocholesterolemia, and hypotocoferolemia with simultaneous accumulation of circulating LPO products 96 h after the administration of alloxan. The severity of hyperglycemia and hypertriglyceridemia decreased, hypercholesterolemia developed, hypotocoferolemia returned to normal, and the tendency to LPO inhibition was observed in rats 10 days after alloxan administration against the background of previous one-week treatment with insulin. In 17 days after the induction of alloxan diabetes preceded by two-week insulin therapy, the content of lipoperoxides reduced below the normal values with simultaneous progression of hypercholesterolemia, hypertriglyceridemia and the increase in serum fructosamine.