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Review
. 2013 Jun;131(6):474-80.
doi: 10.1016/j.thromres.2013.04.017. Epub 2013 May 10.

The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?

Nader Joghetaei  1 , Andreas Stein, Robert A Byrne, Christian Schulz, Lamin King, Andreas E May, Roland Schmidt
Affiliations
Review

The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?

Nader Joghetaei et al. Thromb Res. 2013 Jun.

Abstract

The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN-associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal role of EMMPRIN in the complex processes of atherogenesis, atheroprogression, and acute atherosclerothrombosis, a role that goes beyond that of a mere marker of inflammation.

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