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Review
. 2013 Oct;25(10):1955-61.
doi: 10.1016/j.cellsig.2013.04.009. Epub 2013 May 11.

Signaling networks of Rho GTPases in cell motility

Samer Hanna  1 , Mirvat El-Sibai
Affiliations
Free article
Review

Signaling networks of Rho GTPases in cell motility

Samer Hanna et al. Cell Signal. 2013 Oct.
Free article

Abstract

The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis.

Keywords: Actin; Cancer; Motility; PI3K; Rho GTPases.

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