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. 2013 May 9;8(5):e62725.
doi: 10.1371/journal.pone.0062725. Print 2013.

Prevalence of subjective olfactory dysfunction and its risk factors: korean national health and nutrition examination survey

Woo Hyun Lee  1 , Jee Hye Wee, Dong-Kyu Kim, Chae-Seo Rhee, Chul Hee Lee, Soyeon Ahn, Ju Hyun Lee, Yang-Sun Cho, Kun Hee Lee, Kyung Soo Kim, Si Whan Kim, Ari Lee, Jeong-Whun Kim
Affiliations

Prevalence of subjective olfactory dysfunction and its risk factors: korean national health and nutrition examination survey

Woo Hyun Lee et al. PLoS One. .

Abstract

Background: Population-based studies for olfactory dysfunction are lacking. The aim of this study is to evaluate the prevalence of subjective olfactory dysfunction and its risk factors in the Korean general population.

Methods: The data were obtained from the 2009 Korea National Health and Nutrition Examination Survey (KNHANES), which was a cross-sectional survey of non-institutionalized population all around the country (n = 10,533). All interviewees underwent medical interviews, physical examinations, endoscopic examination and blood/urine tests. Whether sense of smell has been normal or abnormal during the last 3 months was asked. Complete olfaction data were obtained from 7,306 participants and the participants were divided into normosmic and hyposmic group. Multivariate logistic regression analyses were performed to identify its risk factors.

Results: The weighted prevalence of subjective olfactory dysfunction was 4.5%. Its increased prevalence was significantly associated with the increasing age for both men and women. In the multivariate analyses, low income (adjusted odds ratio [OR] = 1.43, 95% Confidence Interval [CI] = 1.01-2.03), habitual exposure to air pollutants (adjusted OR = 2.18, CI = 1.33-3.55), a history of hepatitis B (adjusted OR = 3.10, CI = 1.25-7.68), rhinitis (adjusted OR = 1.78, CI = 1.26-2.51) and chronic sinusitis (adjusted OR = 14.55, CI = 10.06-21.05) were risk factors of olfactory dysfunction.

Conclusion: Our population-based study showed that olfactory dysfunction was quite prevalent and several risk factors were associated with impaired sense of smell. Given its prevalence, further researches for its prevention and management are required.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Prevalence of subjective olfactory dysfunction by age groups and genders.
There were increasing tendency of olfactory dysfunction prevalence with increasing age in both genders, asterisk; p<0.05.
See this image and copyright information in PMC

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