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. 2013:2013:151675.
doi: 10.1155/2013/151675. Epub 2013 Feb 26.

Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension

Chuchen Meng  1 , Min Sun, Zhixiao Wang, Qi Fu, Mengdie Cao, Zhenxin Zhu, Jia Mao, Yun Shi, Wei Tang, Xiaoping Huang, Yu Duan, Tao Yang
Affiliations

Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension

Chuchen Meng et al. J Diabetes Res. 2013.

Abstract

Aim. We investigated the relationship between brachial-ankle pulse wave velocity (baPWV) and glucose levels, insulin sensitivity, and beta-cell function in Chinese individuals with or without hypertension. Methods. We recruited 3137 nondiabetic individuals whose age, body mass index (BMI), glucose levels, blood pressure (BP), lipids, hemoglobin A1C (HbA1c), baPWV, and insulin levels were measured. Results. In normotensive group, 2 h glucose levels (β = 0.046, P < 0.001) associated with baPWV, showed a significant increase in patients with NG as compared to those with DM (P = 0.032). The hypertensive group showed no such differences. The Matsuda index (β = 0.114, P < 0.001) and HOMA- β (β = 0.045, P < 0.001) were negatively correlated with baPWV while lnHOMA-IR (β = 0.196, P = 0.076) and the Quantitative Insulin Sensitivity Check Index (QUICKI) (β = 0.226, P = 0.046) showed a borderline negative correlation. BaPWV significantly decreased (P = 0.032) with an increase in insulin sensitivity in individuals with both normal BP and glucose tolerance. Conclusions. BaPWV was significantly associated with 2 h glucose levels, insulin sensitivity and beta-cell function in normotensive population, whereas in hypertensive individuals, BP was the dominant factor influencing arterial stiffness. Individuals with abnormal insulin sensitivity in the absence of diabetes and hypertension are also at an increased risk of arterial stiffness.

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Figures

Figure 1
Figure 1
(a) Difference in PWV values across the glucose tolerance groups, after adjustment for age, gender, BMI, WHR, TG, lipids, HR, and MAP. P for trend = 0.000, 0.429 in normotensive and hypertensive groups, respectively. (b) Difference in PWV values across the HbA1c groups, after adjustment for age, gender, BMI, WHR, TG, lipids, HR, and MAP. P for trend = 0.001, 0.761 in normotensive and hypertensive groups, respectively.
Figure 2
Figure 2
Difference in PWV values across the quartile of Matsuda's index among nondiabetic people in normotensive group, after adjustment for age, BMI, WHR, lipids, HR, and MAP. P for trend = 0.032; *P < 0.05 versus Q4.
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