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. 2013:2013:232404.
doi: 10.1155/2013/232404. Epub 2013 Feb 26.

Relationship between Oxidant/Antioxidant Markers and Severity of Microalbuminuria in the Early Stage of Nephropathy in Type 2 Diabetic Patients

Ning Shao  1 , Hong Yu Kuang, Na Wang, Xin Yuan Gao, Ming Hao, Wei Zou, Hui Qing Yin
Affiliations

Relationship between Oxidant/Antioxidant Markers and Severity of Microalbuminuria in the Early Stage of Nephropathy in Type 2 Diabetic Patients

Ning Shao et al. J Diabetes Res. 2013.

Abstract

A wide range of microalbuminuria cutoff values are currently used for diagnosing the early stage of nephropathy in type 2 diabetes (T2D). This study analyzed the relationships between oxidant and antioxidant markers of nephropathy and the severity of microalbuminuria. The study included 50 healthy controls (Group 1), 50 diabetic patients with no nephropathy (Group 2), 50 diabetic patients with nephropathy and a urinary albumin excretion (UAE) of 30-200 mg/24 h (Group 3), and 50 diabetic patients with UAE 200-300 mg/24 h (Group 4). Serum nitrotyrosine, conjugated dienes, 8-hydroxy-2'-deoxyguanosine (8-OHdG), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC) levels were determined. Oxidative stress is increased in the early stage of nephropathy in patients with T2D. There was a significant correlation between the extent of microalbuminuria and markers of oxidative stress. Multiple linear regression analysis identified lipid oxidative stress as a possible independent marker for evaluating the degree of renal damage in diabetic nephropathy. Stratifying microalbuminuria values during the early stage of nephropathy might be an important factor in facilitating earlier and more specific interventions.

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Figures

Figure 1
Figure 1
Correlation between microalbuminuria levels and nitrotyrosine.
Figure 2
Figure 2
Correlation between microalbuminuria levels and conjugated dienes.
Figure 3
Figure 3
Correlation between microalbuminuria levels and 8-hydroxy-2′-deoxyguanosine.
Figure 4
Figure 4
Correlation between microalbuminuria levels and superoxide dismutase.
Figure 5
Figure 5
Correlation between microalbuminuria levels and total antioxidant capacity.
See this image and copyright information in PMC

References

    1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice. 2010;87(1):4–14. - PubMed
    1. Piarulli F, Sartore G, Ceriello A, et al. Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients. Diabetologia. 2009;52(7):1419–1425. - PubMed
    1. Rachmani R, Levi Z, Lidar M, Slavachevski I, Half-Onn E, Ravid M. Considerations about the threshold value of microalbuminuria in patients with diabetes mellitus: lessons from an 8-year follow-up study of 599 patients. Diabetes Research and Clinical Practice. 2000;49(2-3):187–194. - PubMed
    1. Stehouwer CDA. Endothelial dysfunction in diabetic nephropathy: state of the art and potential significance for non-diabetic renal disease. Nephrology Dialysis Transplantation. 2004;19(4):778–781. - PubMed
    1. Araki SI, Haneda M, Koya D, Kashiwagi A, Uzu T, Kikkawa R. Clinical impact of reducing microalbuminuria in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice. 2008;82(supplement 1):S54–S58. - PubMed

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