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. 2013 May 14:12:72.
doi: 10.1186/1476-511X-12-72.

Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern

Zhi-Fang Jia  1 , Xue-Yuan Cao, Dong-Hui Cao, Fei Kong, Punyaram Kharbuja, Jing Jiang
Affiliations

Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern

Zhi-Fang Jia et al. Lipids Health Dis. .

Abstract

Background: Previous studies have reported that different genotypes of PTPN11 gene (protein tyrosine phosphatase, non-receptor 11) were associated with different levels of serum lipids. The aim of this study was to explore the relationship between single nucleotide polymorphisms (SNPs) of PTPN11 and serum lipids in Northeast Chinese.

Methods: A total of 1003 subjects, 584 males and 419 females, were included in the study and their serum lipids were determined. Five htSNPs (rs2301756, rs12423190, rs12229892, rs7958372 and rs4767860) of PTPN11 gene were genotyped using TaqMan assay method.

Results: All of the five SNPs were in Hardy-Weinberg equilibrium. The male subjects had higher triglyceride (TG), higher low-density lipoprotein cholesterol (LDL-C) and lower high-density lipoprotein cholesterol (HDL-C) level than females. In males, rs4767860 was found to be associated with serum TG and total cholesterol (TC) levels and rs12229892 was associated with TC level. However, these significant associations could not be observed in females. In females, rs2301756 was found to be associated with TG and rs7958372 was associated with LDL-C level. Haplotype analysis showed that the GCGTG haplotype was associated with slightly higher TG level and ATGCG with higher TC level.

Conclusions: SNPs of PTPN11 may play a role in serum lipids in a sex-specific pattern. However, more studies are needed to confirm the conclusion and explore the underlying mechanism.

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References

    1. Castelli WP, Anderson K, Wilson PW, Levy D. Lipids and risk of coronary heart disease. The Framingham Study. Ann Epidemiol. 1992;2:23–28. doi: 10.1016/1047-2797(92)90033-M. - DOI - PubMed
    1. Kannel WB, Gordon T, Dawber TR. Role of lipids in the development of brain infarction: the Framingham study. Stroke. 1974;5:679–685. doi: 10.1161/01.STR.5.6.679. - DOI - PubMed
    1. Boden WE. High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: assessing the data from Framingham to the Veterans Affairs High–Density Lipoprotein Intervention Trial. Am J Cardiol. 2000;86:19L–22L. - PubMed
    1. Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF, Whelton PK, He J. Prevalence of the metabolic syndrome and overweight among adults in China. Lancet. 2005;365:1398–1405. doi: 10.1016/S0140-6736(05)66375-1. - DOI - PubMed
    1. Thomsen SB, Rathcke CN, Skaaby T, Linneberg A, Vestergaard H. The association between genetic variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and the lipid profile in a danish population. PLoS One. 2012;7:e47094. doi: 10.1371/journal.pone.0047094. - DOI - PMC - PubMed

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