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. 2013 Aug;92(8):974-7.
doi: 10.1111/aogs.12155. Epub 2013 May 15.

Histidine-rich glycoprotein gene polymorphism in patients with recurrent miscarriage

Karin E Lindgren  1 , Karin Kårehed, Helena Karypidis, Frida Hosseini, Katarina Bremme, Britt-Marie Landgren, Lottie Skjöldebrand-Sparre, Anneli Stavreus-Evers, Inger Sundström-Poromaa, Helena Akerud
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Free article

Histidine-rich glycoprotein gene polymorphism in patients with recurrent miscarriage

Karin E Lindgren et al. Acta Obstet Gynecol Scand. 2013 Aug.
Free article

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Acta Obstet Gynecol Scand. 2016 Dec;95(12):1450. doi: 10.1111/aogs.13049. Acta Obstet Gynecol Scand. 2016. PMID: 27873313 No abstract available.

Abstract

Association between the histidine-rich glycoprotein (HRG) C633T single nucleotide polymorphism (SNP) and recurrent miscarriage was investigated in a case-control study. The cases constituted 187 women with recurrent miscarriage that were compared with 395 controls who had delivered a child and had no history of miscarriage. Blood samples were collected from each woman, genomic DNA was extracted and genotyped for the HRG C633T SNP. In the whole study population, the percentage of miscarriage was the same, regardless of genotype (C/C 31.2%, C/T 32.9% and T/T 32.5%). However, an association between homozygous T/T carriers and recurrent miscarriage was detected in a subgroup of women with primary recurrent miscarriage (odds ratio 2.44, 95% CI 1.01-5.92). Our results indicate an important role for the HRG C633T SNP in the occurrence of recurrent miscarriage.

Keywords: Genotype; histidine-rich glycoprotein; infertility; recurrent miscarriage; single nucleotide polymorphism.

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