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Comment
. 2013:8:495.
doi: 10.2147/CIA.S44638. Epub 2013 May 8.

Response to Alzheimer's research paper

H Mina Tait
Comment

Response to Alzheimer's research paper

H Mina Tait. Clin Interv Aging. 2013.
No abstract available

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Figures

Figure 3
Figure 3
Atorvastatin attenuated interleukin-1β expression in the hippocampus of a rat treated with Aβ1-42. The upper panel shows interleukin-1β-positive cells in rat hippocampus, detected by immunohistochemistry on day 7 after Aβ injection (original magnification × 400). (A) Control group (group 1), (B) atorvastatin control group (group 2), (C) AD group (group 3), and (D) atorvastatin-treated AD group (group 4). (E) The lower panel shows the number of interleukin-1β-positive cells counted in the rat hippocampus. Notes: The data are presented as the mean ± standard deviation. *P < 0.01. Abbreviations: Aβ, amyloid-beta peptide; IL, interleukin; AD, Alzheimer’s disease.
Figure 4
Figure 4
Atorvastatin attenuated interleukin-6 expression in the hippocampus of a rat treated with Aβ 1-42. The upper panel shows interleukin-6-positive cells in rat hippocampus, detected by immunohistochemistry on day 7 after Aβ injection (original magnification × 400). (A) Control group (group 1), (B) atorvastatin control group (group 2), (C) AD group (group 3), and (D) atorvastatin-treated AD group (group 4). (E) The lower panel shows the number of interleukin-6-positive cells counted in the rat hippocampus. Notes: The data are presented as the mean ± standard deviation. *P < 0.01. Abbreviations: Aβ, amyloid-beta (peptide); IL, interleukin; AD, Alzheimer’s disease.
Figure 5
Figure 5
Atorvastatin attenuated TNF-α expression in hippocampus of the Aβ1-42-treated rat. The upper panel shows TNF-α-positive cells in rat hippocampus, detected by immunohistochemistry on day 7 after Aβ injection (original magnification × 400). (A) Control group (group 1), (B) atorvastatin control group (group 2), (C) AD group (group 3), and (D) atorvastatin-treated AD group (group 4). (E) The lower panel shows the number of TNF-α-positive cells counted in the rat hippocampus. Notes: The data are presented as the mean ± standard deviation. *P < 0.01. Abbreviations: Aβ, amyloid-beta (peptide); IL, interleukin; AD, Alzheimer’s disease; TNF-α, tumor necrosis factor alpha.
See this image and copyright information in PMC

Comment in

  • Response.
    Li XH. Li XH. Clin Interv Aging. 2013;8:496-9. Clin Interv Aging. 2013. PMID: 23814879 No abstract available.

Comment on

References

    1. Zhang YY, Fan YC, Wang M, Wang D, Li XH. Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer’s disease. Clin Interv Aging. 2013;8:103–110. - PMC - PubMed
    1. Buxbaum JD, Geoghagen NS, Friedhoff LT. Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. J Alzheimers Dis. 2001;3:221–229. - PubMed

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