Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jun;2(2):166-71.

Haplotype Based Association Study between t-PA Gene and Essential Hypertension

Kosuke Saito  1 , Tomohiro Nakayama, Naoyuki Sato, Yoshiyuki Kaneko, Ichiro Sato, Akihiko Morita, Teruyuki Takahashi, Masayoshi Soma, Ron Usami
Affiliations

Haplotype Based Association Study between t-PA Gene and Essential Hypertension

Kosuke Saito et al. Int J Biomed Sci. 2006 Jun.

Abstract

Several previous studies have shown that essential hypertension (EH) is associated with fibrinolysis. Tissue plasminogen activator (t-PA) plays a key role in fibrinolysis. Thus, it is possible that the t-PA gene is a susceptibility gene of EH. However, there have been no reported studies of association between EH and the t-PA gene using single nucleotide polymorphisms (SNPs). The aim of the present haplotype-based case-control study was to investigate whether SNPs in the human t-PA gene are associated with EH. We performed a genetic association study using 3 SNPs (rs7007329, rs8178750, rs4471024). The subjects were 276 EH patients and 283 age-matched normotensive (NT) individuals. There were no significant differences in overall distribution of genotypes or alleles between EH patients and NT subjects. Also, there were no significant differences in the haplotype-based case-control study. The present results do not indicate an association between the t-PA gene and EH.

Keywords: association study; essential hypertension; genetic; haplotype; single nucleotide polymorphism; tissue plasminogen activator.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Organization of the human t-PA gene and location of the SNPs used for the association analysis. Closed black boxes indicate exons, and lines indicate introns.
See this image and copyright information in PMC

References

    1. Colhoun H. Confirmation needed for genes for hypertension. Lancet. 1999;353:1200–1201. - PubMed
    1. Donders SH, Lustermans FA, van Wersch JW. Fibrinolysis factors and lipid composition of the blood in treated and untreated hypertensive patients. Blood Coagul. Fibrinolysis. 1992;3:61–67. - PubMed
    1. Makris TK, Stavroulakis GA, Hatzizacharias AN, et al. Parental history of hypertension is associated with coagulation-fibrinolytic balance disorders. Thromb. Res. 2003;111:45–49. - PubMed
    1. Kooistra T, Schrauwen Y, Arts J, Emeis JJ. Regulation of endothelial cell t-PA synthesis and release. Int. J. Hematol. 1994;59:233–255. - PubMed
    1. Ridker PM, Vaughan DE, Stampfer MJ, et al. Endogenous tissue-type plasminogen activator and risk of myocardial infarction. Lancet. 1993;341:1165–1168. - PubMed

LinkOut - more resources