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. 2011 Mar;7(1):6-13.

Correlation of oxidative stress parameters and inflammatory markers in tunisian coronary artery disease patients

Azza Dandana  1 , Imen Gammoudi, Salima Ferchichi, Hinda Chahed, Hlima Ben Limam, Faouzi Addad, Abdelhedi Miled
Affiliations

Correlation of oxidative stress parameters and inflammatory markers in tunisian coronary artery disease patients

Azza Dandana et al. Int J Biomed Sci. 2011 Mar.

Abstract

Introduction: Oxidative stress is now recognized as being the cause and the consequence of cardiovascular diseases.

Objective: The role that oxidative stress parameters and inflammatory markers may play in diabetes and related cardiovascular disease (CVD) among Tunisian coronary diabetic patients.

Patients and methods: We measured the erythrocyte glutathione peroxidase (GPX), the superoxide dismutase (SOD) activities and the plasmatic total antioxidant status (TAS) concentration by colorimetric methods, the hs-CRP by immunonephelometry assays.

Results: TAS and GPX were significantly decreased among patients compared to the controls (1.14 ± 0.28 mmol/l vs 1.55 ± 0.35 mmol/l; 59.32 ± 10.72 U/gHb vs 149.19 ± 30.95 U/gHb). For the diabetic patients, TAS is correlated positively with hs-CRP (r=0.01, p<10(-3)). At the not diabetic subjects, TAS is correlated negatively with the hsCRP.

Conclusion: Determination of antioxidative defense markers contributes to understanding the effect of stress oxidative on the development and the prevention of cardiovascular disease.

Keywords: cardiovascular diseases; diabetes; glutathione peroxidase (GPX); high sensitivity C reactive protein (hs-CRP); total antioxidant status (TAS).

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Figures

Figure 1
Figure 1
In coronary diabetic patients, Pearson’s correlation coefficient revealed significant positive correlation between TAS and glucose (r=0,224, p<10-3).
Figure 2
Figure 2
In the coronary none diabetic subjects, the TAS presents a significant negative correlation with glucose (r=-0.102, p<10-3).
Figure 3
Figure 3
Coronary patients with diabetic complications had significantly negative correlation between GPX-glucose (r=-0.160, p<10-3).
Figure 4
Figure 4
In coronary patients without diabetic complications, Pearson’s correlation revealed a positive significantly correlation between GPX-glucose (r=0.129, p<10-3).
Figure 5
Figure 5
Coronary patients with diabetic complications had significantly negative correlation between SOD-glucose (r=-0.202, p<10-3).
Figure 6
Figure 6
In coronary patients without diabetic complications, Pearson’s correlation revealed a positive significantly correlation between SOD-glucose (r=0,112, p<10-3).
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