Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Sep;7(3):158-71.

Genetic variation and its role in malignancy

Bente A Talseth-Palmer  1 , Rodney J Scott
Affiliations

Genetic variation and its role in malignancy

Bente A Talseth-Palmer et al. Int J Biomed Sci. 2011 Sep.

Abstract

Genetic variation has long been thought associated with common complex disease and has therefore been widely studied. Genetic variation in the human genome is present in many forms and have been summarised in this review. The potential role of DNA damage, DNA repair and environmental influence on genetic variation in the development of cancer will be discussed, before significant genome projects are reviewed. All the various forms of genetic variation have been associated with malignancies and have been extensively studied and this is a review of the state of the field. We also discuss the road ahead in fulfilling the ultimate goal in all cancer genetic studies, which is decreasing deaths caused by cancer.

Keywords: DNA damage and repair; environmental influence; genetic variation; malignancy.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Schmith VD, Campbell DA, Sehgal S, et al. Pharmacogenetics and disease genetics of complex diseases. Cell Mol. Life Sci. 2003;60(8):1636–1646. - PMC - PubMed
    1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57–70. - PubMed
    1. Eccles D, Tapper W. The influence of common polymorphisms on breast cancer. Cancer Treat Res. 2010;155:15–32. - PubMed
    1. Nevo E. Genetic variation in natural populations: patterns and theory. Theor. Popul. Biol. 1978;13(1):121–177. - PubMed
    1. Kaneko K, Furusawa C. An evolutionary relationship between genetic variation and phenotypic fluctuation. J. Theor. Biol. 2005 - PubMed

LinkOut - more resources