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Multicenter Study
. 2013 May 10;8(5):e62985.
doi: 10.1371/journal.pone.0062985. Print 2013.

The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population

Roberto de Marco  1 , Giancarlo Pesce, Alessandro Marcon, Simone Accordini, Leonardo Antonicelli, Massimiliano Bugiani, Lucio Casali, Marcello Ferrari, Gabriele Nicolini, Maria Grazia Panico, Pietro Pirina, Maria Elisabetta Zanolin, Isa Cerveri, Giuseppe Verlato
Affiliations
Multicenter Study

The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population

Roberto de Marco et al. PLoS One. .

Abstract

Background: The joint distribution of asthma and chronic obstructive pulmonary disease (COPD) has not been well described. This study aims at determining the prevalence of self-reported physician diagnoses of asthma, COPD and of the asthma-COPD overlap syndrome and to assess whether these conditions share a common set of risk factors.

Methods: A screening questionnaire on respiratory symptoms, diagnoses and risk factors was administered by mail or phone to random samples of the general Italian population aged 20-44 (n = 5163) 45-64 (n = 2167) and 65-84 (n = 1030) in the frame of the multicentre Gene Environment Interactions in Respiratory Diseases (GEIRD) study.

Results: A physician diagnosis of asthma or COPD (emphysema/chronic bronchitis/COPD) was reported by 13% and 21% of subjects aged <65 and 65-84 years respectively. Aging was associated with a marked decrease in the prevalence of diagnosed asthma (from 8.2% to 1.6%) and with a marked increase in the prevalence of diagnosed COPD (from 3.3% to 13.3%). The prevalence of the overlap of asthma and COPD was 1.6% (1.3%-2.0%), 2.1% (1.5%-2.8%) and 4.5% (3.2%-5.9%) in the 20-44, 45-64 and 65-84 age groups. Subjects with both asthma and COPD diagnoses were more likely to have respiratory symptoms, physical impairment, and to report hospital admissions compared to asthma or COPD alone (p<0.01). Age, sex, education and smoking showed different and sometimes opposite associations with the three conditions.

Conclusion: Asthma and COPD are common in the general population, and they coexist in a substantial proportion of subjects. The asthma-COPD overlap syndrome represents an important clinical phenotype that deserves more medical attention and further research.

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Conflict of interest statement

Competing Interests: The authors confirm that Gabriele Nicolini is an employe of the “Chiesi Farmaceutici, Parma, Italy,” one of the commercial funders of this research. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Figures

Figure 1
Figure 1. Prevalence* of self-reported physician-diagnosed asthma and/or COPD in the Italian population.
*Adjusted for season, cumulative percentile rank of response, type of survey (postal waves/telephone) and centre.
See this image and copyright information in PMC

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