Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jun;13(6):432-6.
doi: 10.1038/nrc3535. Epub 2013 May 16.

The hen as a model of ovarian cancer

Patricia A Johnson  1 , James R Giles
Affiliations

The hen as a model of ovarian cancer

Patricia A Johnson et al. Nat Rev Cancer. 2013 Jun.

Abstract

The domestic laying hen is the only non-human animal that spontaneously develops ovarian cancer with a high prevalence. Hens ovulate prolifically, and this has made the hen intuitively appealing as a model of this disease in light of epidemiological evidence that ovulation rate is highly correlated with the risk of human ovarian cancer. As in women, ovarian cancer in the hen is age-related and it is also grossly and histologically similar to that in humans. In both women and hens, the cancer metastasizes to similar tissues with an accumulation of ascites fluid. Some aggressive ovarian cancers in women arise from cells in the oviduct; this is intriguing because ovarian cancers in the hen express an oviductal protein that is normally absent in the ovary.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12505-9 - PubMed
    1. J Ultrasound Med. 2011 Mar;30(3):333-45 - PubMed
    1. Biosci Rep. 2012 Feb;32(1):1-15 - PubMed
    1. Exp Biol Med (Maywood). 2006 Dec;231(11):1718-25 - PubMed
    1. Anal Bioanal Chem. 2010 Sep;398(2):737-49 - PubMed

MeSH terms