Epidemiology of chronic inflammatory neuropathies in southeast England

Abstract

Background and purpose: There is little information about the prevalence and disease burden of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraproteinaemic demyelinating neuropathy (PDN).

Methods: Multiple sources were used to study the prevalence and clinical features of these diseases in a southeast England population of 3,557,352 people.

Results: The crude prevalences were as follows: CIDP, 2.84 (95% CI 2.31-3.45); MMN, 0.53 (95% CI 0.32-0.83); and PDN, 1.04 (95% CI 0.73-1.43) per 100,000 population. All three diseases were more common in men than in women. The peak decade of onset was older in those with CIDP (70-79 years) and PDN (70-79 years) than in those with MMN (50-59 years). Disability was greater in CIDP and PDN, with median (range) overall neuropathy limitations scores of 4 (0-8) and 4 (1-6), respectively, than in MMN, with a score of 2 (1-5).

Conclusion: The common forms of chronic inflammatory neuropathy cause a considerable disease burden in the community.

Keywords: chronic inflammatory demyelinating polyradiculoneuropathy; disability; epidemiology; multifocal motor neuropathy; paraproteinaemic demyelinating neuropathy.