MicroRNAs in myeloid malignancies

Abstract

MicroRNAs (miRNAs) are key to the pathogenesis of human malignancies and increasingly recognized as potential biomarkers and therapeutic targets. Haematological malignancies, being the earliest human malignancies linked to aberrant miRNA expression, have consistently underpinned our understanding of the role that miRNAs play in cancer development. Here, we review the expanding roles attributed to miRNAs in the pathogenesis of different types of myeloid malignancies and highlight key findings.

Keywords: acute myeloid leukaemia; chronic myeloid leukaemia; leukaemia; microRNAs; myeloid.