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Comment
. 2013 May 13;23(5):561-3.
doi: 10.1016/j.ccr.2013.04.021.

A new mode of RAF autoregulation: a further complication in the inhibitor paradox

Fiona Hey  1 , Catrin Pritchard
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A new mode of RAF autoregulation: a further complication in the inhibitor paradox

Fiona Hey et al. Cancer Cell. .
Free article

Abstract

ERK pathway activation in cells expressing wild-type BRAF is a well-reported, clinically-relevant adverse effect of the otherwise impressive response of BRAF(V600E)-mutated melanomas to RAF inhibitors. In this issue of Cancer Cell, Holderfield and colleagues show that RAF autoinhibition underpins this paradox, further complicating therapeutic strategies centered around RAF.

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