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Comment
. 2013 May 13;23(5):563-5.
doi: 10.1016/j.ccr.2013.04.028.

EZH2: an epigenetic gatekeeper promoting lymphomagenesis

Holger Heyn  1 , Manel Esteller
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Free article
Comment

EZH2: an epigenetic gatekeeper promoting lymphomagenesis

Holger Heyn et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Béguelin and colleagues highlight EZH2 as an essential regulator for B cell activation and report an addiction of germinal center-derived neoplasms to EZH2 activity. This reversible process is specifically targetable and hence presents high translational value for lymphoma therapy.

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  • EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
    Béguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SN, Wang L, Ezponda T, Martinez-Garcia E, Zhang H, Zheng Y, Verma SK, McCabe MT, Ott HM, Van Aller GS, Kruger RG, Liu Y, McHugh CF, Scott DW, Chung YR, Kelleher N, Shaknovich R, Creasy CL, Gascoyne RD, Wong KK, Cerchietti L, Levine RL, Abdel-Wahab O, Licht JD, Elemento O, Melnick AM. Béguelin W, et al. Cancer Cell. 2013 May 13;23(5):677-92. doi: 10.1016/j.ccr.2013.04.011. Cancer Cell. 2013. PMID: 23680150 Free PMC article.

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