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Comment
. 2013 May 13;23(5):567-9.
doi: 10.1016/j.ccr.2013.04.025.

Chromoplexy: a new category of complex rearrangements in the cancer genome

Michael M Shen  1
Affiliations
Comment

Chromoplexy: a new category of complex rearrangements in the cancer genome

Michael M Shen. Cancer Cell. .

Abstract

Widespread structural alterations of cancer genomes are increasingly observed in a broad spectrum of tumors. In a recent issue of Cell, Baca and colleagues describe large chains of rearrangements that coordinately affect multiple chromosomes in prostate cancer. This phenomenon of chromoplexy may define cancer subtypes and drive punctuated tumor evolution.

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Figures

Figure 1
Figure 1. Comparison of chromoplexy and chromothripsis
Shown are schematic representations of chromosomal rearrangements that occur in tumor genomes as a consequence of chromoplexy (top) or chromothripsis (bottom).
See this image and copyright information in PMC

Comment on

  • Punctuated evolution of prostate cancer genomes.
    Baca SC, Prandi D, Lawrence MS, Mosquera JM, Romanel A, Drier Y, Park K, Kitabayashi N, MacDonald TY, Ghandi M, Van Allen E, Kryukov GV, Sboner A, Theurillat JP, Soong TD, Nickerson E, Auclair D, Tewari A, Beltran H, Onofrio RC, Boysen G, Guiducci C, Barbieri CE, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Ramos AH, Winckler W, Cipicchio M, Ardlie K, Kantoff PW, Berger MF, Gabriel SB, Golub TR, Meyerson M, Lander ES, Elemento O, Getz G, Demichelis F, Rubin MA, Garraway LA. Baca SC, et al. Cell. 2013 Apr 25;153(3):666-77. doi: 10.1016/j.cell.2013.03.021. Cell. 2013. PMID: 23622249 Free PMC article.

References

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