Carotid artery intima-media thickness and the renin-angiotensin system
- PMID: 23680737
- PMCID: PMC4040131
- DOI: 10.3810/hp.2013.04.1026
Carotid artery intima-media thickness and the renin-angiotensin system
Abstract
Carotid artery intima-media thickness (IMT) is a biomarker for cardiovascular disease that also predicts the risk of cardiovascular mortality. Angiotensin-converting enzyme (ACE) inhibition is a unique therapeutic modality because it both treats hypertension and improves arterial health and cardiovascular disease outcomes. Controversy exists regarding the role of ACE inhibitors and angiotensin receptor blockers (ARBs) in IMT regression. Our article provides an update on how ACE inhibitors and ARBs could play a role in decreasing IMT.
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References
-
- Murphy SL, Xu J, Kochanek KD. Deaths: preliminary data for 2010. [April 3, 2013];National Vital Statistics Reports. 2012 60(4) http://www.cdc.gov/nchs/data/nvsr/nvsr60/nvsr60_04.pdf. - PubMed
-
- Raitakari OT, Juonala M, Kahonen M, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA. 2003;290(17):2277–2283. - PubMed
-
- Labropoulos N, Leon LR, Jr, Brewster LP, et al. Are your arteries older than your age? Eur J Vasc Endovasc Surg. 2005;30(6):588–596. - PubMed
-
- Poli A, Tremoli E, Colombo A, Sirtori M, Pignoli P, Paoletti R. Ultra-sonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients. A new model for the quantitation and follow-up of preclinical atherosclerosis in living human subjects. Atherosclerosis. 1988;70(3):253–261. - PubMed
-
- O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK., Jr Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999;340(1):14–22. - PubMed
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