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Comparative Study
. 2013 Aug 15;38(18):1561-5.
doi: 10.1097/BRS.0b013e31829a84d2.

Antithrombotic effects of aspirin on 1- or 2-level lumbar spinal fusion surgery: a comparison between 2 groups discontinuing aspirin use before and after 7 days prior to surgery

Jin Hoon Park  1 , Yongchel Ahn, Byeong Sam Choi, Kyu-Taek Choi, Kyuhwak Lee, Se Hun Kim, Sung Woo Roh
Affiliations
Comparative Study

Antithrombotic effects of aspirin on 1- or 2-level lumbar spinal fusion surgery: a comparison between 2 groups discontinuing aspirin use before and after 7 days prior to surgery

Jin Hoon Park et al. Spine (Phila Pa 1976). .

Abstract

Study design: Retrospective clinical analysis.

Objective: To study proper discontinuation date of aspirin in spinal fusion surgery.

Summary of background data: It is thought that excess bleeding can be normalized if aspirin intake is discontinued approximately 7 days before surgery; however, the average life span of a platelet is generally regarded to be 7 to 10 days.

Methods: From January 2004 to December 2009, a single surgeon performed 182 cases of 1- or 2-level lumbar fusion surgical procedures. Patients who were aspirin users (n = 86) were divided into 2 groups according to the number of days prior to surgery that they discontinued their aspirin use: the aspirin 1 group discontinued their aspirin use 3 to 7 days before surgery and the aspirin 2 group discontinued their aspirin use 7 to 10 days before surgery. Ninety-six patients who did not use aspirin before surgery were selected for the control group. We retrospectively compared the several hematological parameters among the 2 aspirin groups and the control group.

Results: Both the total amount of drained blood and the duration of indwelling of the drainage catheter were significantly less in the control group than in the aspirin 1 group in patients who underwent either type of 1-level fusion surgery. However, those were not significantly different between aspirin 2 group and control group in patients who underwent either type of 1-level fusion surgery. Only drainage catheter was significantly less in the control group than in the aspirin 1 group in patients who underwent 2-level fusion surgery.

Conclusion: Only the aspirin 1 group, wherein patients discontinued aspirin use 3 to 7 days before surgery, showed a greater drained blood and drainage catheter than the control group. If aspirin was discontinued 7 days or longer before surgery, there was no difference in the study parameters, compared with the control group.

Level of evidence: 3.

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Comment in

  • Letter.
    Yongjun T. Yongjun T. Spine (Phila Pa 1976). 2014 Mar 1;39(5):454. doi: 10.1097/BRS.0000000000000049. Spine (Phila Pa 1976). 2014. PMID: 24573076 No abstract available.
  • Perioperative aspirin: to give or not to give?
    Sood A, Trinh QD. Sood A, et al. BJU Int. 2014 Sep;114(3):318-9. doi: 10.1111/bju.12525. BJU Int. 2014. PMID: 25156500 No abstract available.

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