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Case Reports
. 2013 Jul;28(7):933-6.
doi: 10.1177/0883073813488664. Epub 2013 May 16.

A novel topical rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex

James W Wheless  1 , Hassan Almoazen
Affiliations
Case Reports

A novel topical rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex

James W Wheless et al. J Child Neurol. 2013 Jul.

Abstract

Facial angiofibromas are dermatological manifestations of tuberous sclerosis complex, a neurocutaneous disorder characterized by excess cell growth and proliferation. Oral rapamycin has been used to treat visceral tuberous sclerosis-related tumors; however, the side effect profile of this medicine precludes its routine use in patients lacking significant internal involvement. The authors formulated a novel rapamycin cream that is easy to compound and apply, does not cause local or systemic side effects, and results in a dramatic improvement of facial angiofibromas.

Keywords: facial angiofibroma; rapamycin; treatment; tuberous sclerosis complex.

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